This work focuses on two case studies and attempts to elucidate the dynamic interaction between feedback control and safety systems in the context of both model-based and classical control systems. In the first case study, the interaction of a model predictive control (MPC) system with a safety system is studied in the context of the methyl isocyanate (MIC) hydrolysis reaction in a continuous stirred tank reactor (CSTR) to avoid thermal runaway. We develop a specific action for the MPC to take when the safety system is activated due to significant feed disturbances that lead to thermal runaway conditions. In the second case study, we focus on a high-pressure flash drum separator for which the temperature, level, and pressure can be regulated using proportional-integral (PI) controllers. Using a large-scale dynamic process simulator, we demonstrate that modifying the tuning parameters of one of these PI controllers based on the safety system being on or off leads to improved closed loop performance compared to the case in which the tuning parameters of the PI controller remain the same regardless of the state of the safety system. (C) 2018 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.