Preparation and anticancer effect of pegylated-chlorambucil prodrug nanoparticle for enhanced therapeutic efficiency

Eun-Hee Jeong; Gyeong-Won Jeong; Jae-Woon Nah

Journal of Industrial and Engineering Chemistry, Vol.64, 438-445, August, 2018

DOI10.1016/j.jiec.2018.03.040 Export Citation

Preparation and anticancer effect of pegylated-chlorambucil prodrug nanoparticle for enhanced therapeutic efficiency

Eun-Hee Jeong, Gyeong-Won Jeong, and Jae-Woon Nah^†

Department of Polymer Science and Engineering, Sunchon National University, Jeonnam 57922, Republic of Korea

E-mail:

Chlorambucil (CLB), which is well known as a therapeutic agent of leukemia and Hodgkin’s disease, has been reported to have anticancer effects against various cancer cells. However, hydrophobic CLB has many problems, including being inefficient and producing side effects because of its low solubility in water. For these reasons, we developed a pegylated-CLB (PCLB and mPCLB) prodrug nanoparticle, which demonstrated excellent dispersibility, high anticancer activity and superior intracellular uptake. These results suggest that PCLB and mPCLB prodrug can use as anticancer agents against various cancer cells.

Keywords:Chlorambucil;Pegylated CLB;Prodrug nanoparticle;Anticancer effect

[References]

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[1] Fabiilli ML, Haworth KJ, Sebastian IE, Kripfgans OD, Carson PL, Fowlkes JB, Ultrasound Med. Biol., 36, 1364 (2010)

[2] Guaragna A, Chiaviello A, Paolella C, D'Alonzo D, Palumbo G, Palumbo G, Bioconjug. Chem., 23, 84 (2012)

[3] Saha B, Haldar U, De P, Macromol. Rapid Commun., 37(13), 1015 (2016)

[4] Venkatesh Y, Karthik S, Rajesh Y, Mandal M, Jana A, Singh ND, Chem. Asian J., 11, 3482 (2016)

[5] Zhang Q, Zhang L, Li Z, Xie X, Gao X, Xu X, Y. Venkatesh, S. Karthik, Y. Rajesh, M. Mandal, A. Jana, N.D. Singh, 18, 2977 (2017)

[6] Soler M, Gonzalez-Bartulos M, Figueras E, Ribas X, Costas M, Massaguer A, Planas M, Feliu L, Org. Biomol. Chem., 13, 1470 (2015)

[7] Bisht R, Mandal A, Jaiswal JK, Rupenthal ID, Nanomed. Nanobiotechnol., 10 (2017)

[8] Dua K, Bebawy M, Awasthi R, Tekade RK, Tekade M, Gupta G, Pinto TDJA, Hansbro PM, Pharm. Nanotechnol., 5 (2017)

[9] Hervault A, Dunn AE, Lim M, Boyer C, Mott D, Maenosono S, Thanh NT, Nanoscale, 8, 12152 (2016)

[10] Kim TH, Jeong GW, Nah JW, J. Ind. Eng. Chem., 54, 298 (2017)

[11] Banerjee SS, Chen DH, Nanotechnology, 19, 265602 (2008)

[12] Jeong GW, Nah JW, Park JK, Appl. Chem. Eng., 28(4), 404 (2017)

[13] Sah AK, Vyas A, Suresh PK, Gidwani B, Artif. Cells Nanomed. Biotechnol., 1 (2017).

[14] Choi C, Nam JP, Nah JW, J. Ind. Eng. Chem., 33, 1 (2016)

[15] Choi C, Lee HY, Jeong YI, Nah JW, J. Ind. Eng. Chem., 47, 112 (2017)

[16] Fang J, Nakamura H, Maeda H, Adv. Drug Deliv. Rev., 63, 136 (2011)

[17] Maeda H, Bharate GY, Daruwalla J, Eur. J. Pharm. Biopharm., 71, 409 (2009)

[18] Chen J, Wu Q, Luo L, Wang Y, Zhong Y, Dai HB, Sun D, Luo ML, Wu W, Wang GX, Int. J. Nanomed., 12, 5745 (2017)

[19] Shen Z, Loe DT, Awino JK, Kroger M, Rouge JL, Li Y, Nanoscale, 8, 14821 (2016)

[20] Vasconcelos A, Vega E, Perez Y, Gomara MJ, Garcia ML, Haro I, Int. J. Nanomed., 10, 609 (2015)

[21] Hartveit F, Acta Pathol. Microbiol. Scand., 77, 639 (1969)

[22] Besterman JM, Low RB, Biochem. J., 210, 1 (1983)

[23] Bloom WS, Puszkin S, Mt. Sinai J. Med., 48, 397 (1981)

[24] Godlee C, Kaksonen M, J. Cell Biol., 203, 717 (2013)

[25] Schubert KO, Focking M, Prehn JH, Cotter DR, Mol. Psychiatry, 17, 669 (2012)

[26] Bach G, Pflugers Arch., 451, 313 (2005)

[27] Nakase I, Kobayashi NB, Takatani-Nakase T, Yoshida T, Sci. Rep., 5, 10300 (2015)

[28] Wu XM, Gehring W, Biochem. Biophys. Res. Commun., 443(4), 1136 (2014)

[29] Naota M, Shimada A, Morita T, Yamamoto Y, Inoue K, Takano H, Toxicol. Pathol., 41, 487 (2013)

[30] Hao X, Wu J, Shan Y, Cai M, Shang X, Jiang J, Wang H, J. Phys. Condens. Matter, 24, 164207 (2012)

[31] Kiss AL, Adv. Exp. Med. Biol., 729, 14 (2012)