Antioxidant Activity and Oxidative Injury Rehabilitation of Chemically Modified Polysaccharide (TAPA1) from Tremella aurantialba

Xiuju Du; Xuandong Wang; Yun Chen; Shuyu Tian; Shifeng Lu

Macromolecular Research, Vol.26, No.6, 479-483, June, 2018

DOI10.1007/s13233-018-6078-0 Export Citation

Antioxidant Activity and Oxidative Injury Rehabilitation of Chemically Modified Polysaccharide (TAPA1) from Tremella aurantialba

Xiuju Du^†, Xuandong Wang, Yun Chen, Shuyu Tian, and Shifeng Lu

College of Life Science, Liaocheng University, Liaocheng, Shandong 252059, P. R. China

E-mail:

In our previous work, an acidic homogenous polysaccharide TAPA1 purified from Tremella aurantialba and its acetylated derivative TAPA1-ac, deacetylated derivative TAPA1-deac and sulfated fractions TAPA1-s were obtained by chemical modification and their partially chemical characterization were investigated. In present work, the antioxidant activities of various polysaccharides, including TAPA1, and its three derivative fractions, were determined in terms of scavenging of superoxide anion radicals and hydrogen peroxide (H2O2) by using chemiluminescence measurements, and their activities of oxidative injury rehabilitation were assessed by using PC12 oxidative injury model induced with H2O2. In general, compared with TAPA1, TAPA1-ac showed significant antioxidant activities and higher oxidative injury protection effects, whereas TAPA1-deac and TAPA1-s showed lower effects. These findings seemed to suggest that antioxidant effects and rehabilitation effect of oxidative injury, relate to not only different substituted group, but also the content and the degree of substitution (DS) of acetyl group, indicating that acetylation of TAPA1 was an effective means of enhancing its antioxidant activity and rehabilitation effect.

Keywords:Tremella aurantialba polysaccharide;antioxidant activity;PC12 oxidative injury model;chemical modification;radical-scavenging activity

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[2] Zhu ZY, Liu Y, Si CL, Yuan J, Lv Q, Li YY, Dong GL, Liu AJ, Zhang YM, Carbohydr. Polym., 92, 872 (2013)

[3] Wang NN, Zhang Y, Wang XP, Huang XW, Fei Y, Yu Y, Shou D, Int. J. Biol. Macromol., 83, 103 (2016)

[4] Chen SH, Chen HX, Tian JG, Wang YW, Xing LS, Wang J, Carbohydr. Polym., 98, 428 (2013)

[5] Xie JH, Wang ZJ, Shen MY, Nie SP, Gong B, Li HS, Zhao Q, Li WJ, Xie MY, Food Hydrocolloids, 53, 7 (2016)

[6] Tao YZ, Zhang YY, Zhang LN, Int. J. Biol. Macromol., 45, 109 (2009)

[7] Yang JH, Du YM, Huang RH, Wan YY, Li TY, Int. J. Biol. Macromol., 31, 55 (2002)

[8] Wang YF, Yang ZW, Wei XL, Int. J. Biol. Macromol., 47, 534 (2010)

[9] Hu Y, Shi S, Lu L, Teng C, Yu S, Wang X, Yu M, Liang J, Qu J, Macromol. Res., 25(3), 222 (2017)

[10] Liu TX, Zhao MM, Innov. Food Sci. Emerg., 11, 677 (2010)

[11] Zhang YL, Lu XY, Fu ZB, Wang ZB, Zhang JB, Food Chem., 127, 1084 (2011)

[12] Du XJ, Zhang JS, Yang Y, Ye LB, Tang QJ, Jia W, Liu YF, Zhou S, X. Hao R, Gong CY, Pan YJ, Carbohydr. Res., 344, 672 (2009)

[13] Du XJ, Zhang JS, Yang Y, Tang QJ, Jia W, Pan YJ, J. Zhejiang Univ.-Sci B, 11, 437 (2010)

[14] Du XJ, Zhang JS, Liu YF, Tang QJ, Jia W, Yang Y, Pan YJ, Acta Agr. Shanghai, 26, 49 (2010)

[15] Du XJ, Zhang Y, Mu HM, Lv ZW, Yang Y, Zhang JS, Food Hydrocolloids, 43, 459 (2015)

[16] Kiho T, Kochi M, Usui S, Hirano K, Aizawa K, Inakuma T, Biol. Pharm. Bull., 24, 1400 (2001)

[17] Zhang W, Qu W, Zhang X, Acta Nutrimenta Sinica, 26, 300 (2004)

[18] Yuan X, Zhang P, Chen S, J. Fudan Univ., 35, 703 (1996)

[19] Du XJ, Zhang JS, Lv ZW, Ye LB, Yang Y, Tang QJ, Food Chem., 142, 336 (2014)

[20] Du XJ, Mu HM, Zhou S, Zhang Y, Zhu XL, Int. J. Biol. Macromol., 62, 691 (2013)

[21] Vinogradov E, Petersen BO, Duus JO, Wasser S, Carbohydr. Res., 339, 1483 (2004)

[22] Ueno Y, Okamoto Y, Yamauchi R, Kato K, Carbohydr. Res., 101, 160 (1982)

[23] Cui HX, Liu Q, Tao YZ, Zhang HF, Zhang LN, Ding K, Carbohydr. Polym., 74, 771 (2008)

[24] Chen XP, Chen Y, Li SB, Chen YG, Lan JY, Liu LP, Carbohydr. Polym., 77, 389 (2009)

[25] Bi HT, Gao TT, Li ZH, Li J, Yang W, Iteku BJ, Liu EX, Zhou YF, Food Chem., 138, 1470 (2013)

[26] Halliwell B, Gutteridge JM, Biochem. J., 219, 1 (1984)

[27] Ma LS, Chen XX, Zhang Y, Zhang N, Fu LL, Carbohydr. Polym., 89, 371 (2012)