Customized microfluidic reactor based on droplet formation for the synthesis of monodispersed silver nanoparticles

Cheol Hwan Kwak; Sung-Min Kang; Euiyoung Jung; Yuvaraj Haldorai; Young-Kyu Han; Woo-Sik Kim; Taekyung Yu; Yun Suk Huh

Journal of Industrial and Engineering Chemistry, Vol.63, 405-410, July, 2018

DOI10.1016/j.jiec.2018.02.040 Export Citation

Customized microfluidic reactor based on droplet formation for the synthesis of monodispersed silver nanoparticles

Cheol Hwan Kwak¹, Sung-Min Kang¹, Euiyoung Jung², Yuvaraj Haldorai^{3, 4}, Young-Kyu Han³, Woo-Sik Kim², Taekyung Yu^{2, †}, and Yun Suk Huh^{1, †}

¹aWCSL of Integrated Human Airway-on-a-Chip, Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, 100 Inharo, Incheon 22212, Republic of Korea
²Department of Chemical Engineering, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin-si, Gyeonggi-do 17104, Republic of Korea
³Department of Energy and Materials Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Jung-gu, Seoul 04620, Republic of Korea
⁴Department of Nanoscience and Technology, Bharathiar University, Coimbatore, 641046, India

E-mail:,

A customized droplet-based microfluidic reactor was fabricated for the synthesis of silver nanoparticles (Ag NPs) using silver nitrate (AgNO3) and branched polyethyleneimine (BPEI) as a precursor and a reducing agent, respectively. The effects of static mixing, temperature, and the volumetric flow rates of AgNO3 and BPEI on the particle size were investigated. The use of a static mixer and the optimization of the reaction temperature enhanced the monodispersity of the Ag NPs. In addition, the size of the Ag NPs was manipulated by changing the flow rate ratio of AgNO3 to BPEI at 60 °C for 60 min.

Keywords:Customized microfluidic device;Silver nanoparticle;Droplet formation;T-junction;Static mixer

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[Referenced By]

[1] Huebner A, Sharma S, Srisa-Art M, Hollfelder F, Edel JB, deMello AJ, Lab Chip, 8, 1244 (2008)

[2] Boedicker JQ, Li L, Kline TR, Ismagilov RF, Lab Chip, 8, 1265 (2008)

[3] Tarn MD, Pamme N, Expert Rev. Mol. Diagn., 11, 711 (2011)

[4] Xia HM, Wan SYM, Shu C, Chew YT, Lab Chip, 5, 748 (2005)

[5] Tice JD, Song H, Lyon AD, Ismagilov RF, Langmuir, 19(22), 9127 (2003)

[6] Zhao CX, He LZ, Qiao SZ, Middelberg APJ, Chem. Eng. Sci., 66(7), 1463 (2011)

[7] Thorsen T, Roberts RW, Arnold FH, Quake SR, Phys. Rev. Lett., 86, 4163 (2001)

[8] Anna SL, Bontoux N, Stone HA, Appl. Phys. Lett., 82, 364 (2003)

[9] Zeng S, Li B, Su XO, Qin J, Lin B, Lab Chip, 9, 1340 (2009)

[10] Utada AS, Lorenceau E, Link DR, Kaplan PD, Stone HA, Weitz DA, Science, 308, 537 (2005)

[11] Ogonczyk D, Wegrzyn J, Jankowski P, Dabrowski B, Garstecki P, Lab Chip, 10, 1324 (2010)

[12] Devaraju NSGK, Unger MA, Lab Chip, 11, 1962 (2011)

[13] Bhargava KC, Thompson B, Malmstadt N, Proc. Natl. Acad. Sci. U. S. A., 111, 15013 (2014)

[14] Ren K, Zhou J, Wu H, Accounts Chem. Res., 46, 2396 (2013)

[15] Hoang PH, Nguyen CT, Perumal J, Kim DP, Lab Chip, 11, 329 (2011)

[16] Marre S, Jensen KF, Chem. Soc. Rev., 39, 1183 (2010)

[17] Asgar SBA, Preetha J, Andrea P, Ian P, J. Micromech. Microeng., 17, 42 (2007)

[18] Lee KG, Park KJ, Seok S, Shin S, Kim DH, Park JY, Heo YS, Lee SJ, Lee TJ, RSC Adv., 4, 32876 (2014)

[19] Benito-Lopez F, Antonana-Diez M, Curto VF, Diamond D, Castro-Lopez V, Lab Chip, 14, 3530 (2014)

[20] Lin XZ, Terepka AD, Yang H, Nano Lett., 4, 2227 (2004)

[21] He ST, Liu YL, Maeda H, J. Nanopart. Res., 10, 209 (2008)

[22] Baber R, Mazzei L, Thanh NTK, Gavriilidis A, RSC Adv., 5, 95585 (2015)

[23] Wang C, Li J, Sun S, Li X, Wu G, Wang Y, Xie F, Huang Y, RSC Adv., 6, 14016 (2016)

[24] Siegel J, Kvitek O, Ulbrich P, Kolska Z, Slepicka P, Svorcik V, Mater. Lett., 89, 47 (2012)

[25] Wang Z, Xu C, Zhao M, Zhao C, RSC Adv., 4, 47021 (2014)

[26] Dousti MR, Amjad RJ, J. Nanophotonics, 9, 093068 (2015)

[27] Shahzad A, Kim WS, Yu T, RSC Adv., 5, 28652 (2015)

[28] Stone ZB, Stone HA, Phys. Fluids, 17, 063103 (2005)

[29] Bringer MR, Gerdts CJ, Song H, Tice JD, Ismagilov RF, Philos. Trans. R. Soc. Lond. Ser. A-Math. Phys. Eng. Sci., 362, 1087 (2004)

[30] Lorber N, Sarrazin F, Guillot P, Panizza P, Colin A, Pavageau B, et al., Lab Chip, 11, 779 (2011)

[31] Li Y, Reddy RK, Kumar CSSR, Nandakumar K, Biomicrofluidics, 8, 054125 (2014)

[32] Knauer A, Thete A, Li S, Romanus H, Csaki A, Fritzsche W, Kohler JM, Chem. Eng. J., 166(3), 1164 (2011)

[33] Song Y, Hormes J, Kumar CSSR, Small, 4, 698 (2008)

[34] Cathcart N, Frank AJ, Kitaev V, Chem. Commun., 7170 (2009).

[35] Dongjo K, Sunho J, Jooho M, Nanotechnology, 17, 4019 (2006)

[36] Chen M, Feng YG, Wang X, Li TC, Zhang JY, Qian DJ, Langmuir, 23(10), 5296 (2007)

[37] Liu Z, Wang Y, Zu Y, Fu Y, Li N, Guo N, Liu R, Zhang Y, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 42, 31 (2014)

[38] Van Hyning DL, Klemperer WG, Zukoski CF, Langmuir, 17(11), 3120 (2001)

[39] Thanh NTK, Maclean N, Mahiddine S, Chem. Rev., 114(15), 7610 (2014)

[40] Pedro T, Puerto MMD, Sabino VV, Teresita GC, Carlos JS, J. Phys. D-Appl. Phys., 36, R182 (2003)

[41] Agnihotri S, Mukherji S, Mukherji S, RSC Adv., 4, 3974 (2014)

[42] Sharma S, Maurya RA, Min KI, Jeong GY, Kim DP, Angew. Chem.-Int. Edit., 52, 7564 (2013)

[43] Wang Y, Zhang XL, Wang AJ, Li X, Wang G, Zhao L, Chem. Eng. J., 235, 191 (2014)