The quest for efficient and selective catalysts for conversion of glycerol monoglyceride is critical for the development of reliable methods for its synthesis. Thus, various types of catalyst and methods of catalyst manufacturing for conversion of glycerol to monoglycerides have been investigated. Acid-functionalized mesoporous catalysts are emerging as highly efficient catalysts for conversion of glycerol into monoglyceride. The incorporation of acid components into different mesoporous silicas for this application is reviewed in this work. The superiority of mesostructure catalysts in comparison to microporous catalysts has been elucidated in terms of accessibility to active sites, pore diffusion, thermal stability of the catalyst and catalyst reusability. Recent direction of novel acid-functionalized mesoporous catalysts development for this application is also critically reviewed.