Auto-ignition temperature (AIT) is one of the most important parameters to assess potential fire and explosion hazards for chemicals. In this work, the AITs of 132 groups of binary miscible liquid mixtures were measured. Experimental results show the AITs of binary miscible liquid mixtures vary with their volume ratios. Three types of trends representing the relationship between AITs and volume ratios were found. A computational model was established to calculate the AITs of methanol + toluene, ethyl alcohol + toluene, ethyl alcohol + methanol and n-heptane + ethyl alcohol in 6 volume ratios. The calculation results showed that the calculated deviations were within 8% of the experimental results. For higher hydrocarbons, the model suffers from a lack of accurate chemical kinetic data to properly predict the AITs of the mixtures. (C) 2017 Published by Elsevier B.V. on behalf of Institution of Chemical Engineers.