The present study focuses on model based parameter optimization of nanosuspension preparation via wet stirred media milling. Based on experimental data of nanomilling a crystalline organic material, two different approaches for process optimization were evaluated: The stress model for stirred media mills, introduced by Kwade, was compared to the microhydrodynamic approach modified by Bilgili and Afolabi. The different approaches to describe influences of operating parameters were discussed with respect to their applicability on process optimization of nanosuspension preparation. Both approaches yield characteristic values which are derived from proportionalities to process parameters. Despite of different physical assumptions, the milling process can be optimized by both approaches. A more detailed insight into physical interactions can be only generated by numerical procedures. Limitations of the applied procedures were observed especially with respect to the accessibility of parameters required for calculation. (C) 2018 Elsevier B.V. All rights reserved.