In this paper, the low-temperature thermally induced phase separation (L-TIPS) method was adopted to prepare a high-performance polyvinylidene fluoride (PVDF) hydrophobic membrane for membrane distillation (MD) with non-solvent polyethylene glycol-400 (PEG400) and solvent triethyl phosphate as a fully water-soluble mixed diluent. In the process of L-TIPS membrane formation, the unidirectional regulatory role of coagulation bath temperature on cross-section radius of the PVDF hollow-fiber membrane was analyzed. The results show that the tensile strength of the membrane increases with the increase of the external coagulation bath water temperature, which is the opposite of the general rule. PEG400 is employed to regulate the membrane structure, and more specifically to increase the cellular structure (a positive impact on tensile strength) and reduce the sphere-packed aggregation structure (a negative impact on tensile strength). When the coagulation bath temperature is 60 degrees C, the tensile strength of the membrane reaches 6.21 MPa (more than 2-4 times higher than the hydrophobic membranes reported). Meanwhile, the PVDF hollow-fiber hydrophobic membrane also has a high flux, the vacuum membrane distillation flux reaches 30.6 kg m(-2) h(-1), which is 14.6 times higher than that at the coagulation bath temperature of 15 degrees C.