Inspired from the highly bioadhesive performance of polydopamine (pDA)-based layers, a facile method was developed to modify GO nanosheets with pDA (pDA@GO). The key design of the molecularly imprinted nanocomposite membranes (MINMs) was integrated pDA@GO nanosheets into the porous PVDF membranes as the highly adjustable active domains. Dendrites-like 3D Ag microspheres were obtained on the surface of nanosheets-infiltrated nanocomposite membranes (NS-NMs) to obtain high performance membranes. The as-prepared pDA coating layers not only modified GO nanosheets, but also could be used as a versatile platform for the further immobilizing dendrites-like 3D Ag microspheres on the surface of NS-NMs to improve anti-fouling property. Attribute to the highly adjustable active domains and dendrites-like 3D Ag microspheres, the as-prepared MINMs revealed an outstanding adsorption amount (61.55 mg g(-1)), a better hydrophilicity and regenerability. Most importantly, excellent perm-selectivity performance (beta(ketoprofen/ibuprofen) and beta(naproxen) (sodium/ibuprofen) were 6.55 and 6.63, respectively) could be also achieved, which is beneficial to adsorb and separate of ibuprofen.