This study evaluated the effect of different cementing strategies and adhesive interface aging on microtensile bond strength (TBS) of lithium disilicate ceramic (IPS e.max CAD) to dentin. Forty coronal dentin fragments were randomly assigned to four groups according to the cementing strategy used to bond lithium disilicate ceramic to coronal dentin surface (n=10): U200 (self-adhesive resin cement (RC) RelyX U200 (R)/3M ESPE), SBU (single-step self-etching adhesive system (AS) Single Bond Universal (R)/3M ESPE+RelyX ARC (R)/3M ESPE RC), AdperSB (two-step etch-and-rinse AS Single Bond 2 (R)/3M+RelyX ARC (R)/3M ESPE RC) and Scotchbond (three-step etch-and-rinse AS Scotchbond Multi-Purpose (R)/3M+RelyX ARC (R)/3M RC). After 48h, the ceramic-tooth blocks were sectioned perpendicular to the adhesive interface in the form of sticks and randomly subdivided into two groups according to when they were to be submitted to TBS testing: immediately or 6months after storage in water. Some sticks were kept for analysis of the adhesive interface by scanning electron microscopy (SEM). The TBS test was performed in a universal testing machine (0.5mm/min). The data (MPa) were analyzed using split-plot ANOVA and Tukey's test (=0.05). Water storage decreased TBS in all cementing strategies. The TBS was greatest in the Scotchbond group and lowest in the U200 group, at both storage times. No signs of interface degradation were detected under SEM after water storage. In conclusion, water storage decreased bond strength, regardless of the adhesive cementation strategy, and that the three-step adhesive system/dual-cure resin cement ultimately performed better in terms of bond strength.