In this paper, the influence of non-Newtonian rheology of nanofibers on electrospinning process is analyzed numerically. A simple and highly accurate numerical method called the Differential Quadrature Method (DQM), is used for solving the governing equations of electrospinning systems. The validity of the results of DQM solution are verified via comparison with experimental data and a good agreement between the present method and the experimental data is observed. The behavior of the elongation, velocity, stress and total force profiles with variation of some physical parameters are discussed in details. The results show that by increasing the values of yield stress, the fluid elongation is reduced significantly. Furthermore, it is found that Differential Quadrature Method can be easily extended to other strongly nonlinear equations and can be found widely applicable in engineering and science. (C) 2018 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.