Isotope exchange for deuterated gas-phase acetic acid and ethanol in contact with water (H2O) droplets was studied using a droplet train apparatus. In these experiments, the gas-phase species interacts with liquid droplets and the loss of the species is monitored. The loss of the species may be due to the entry of the molecules into the bulk or to a reaction of the species at the gas-liquid interface, in this case isotope exchange. Studies were conducted as a function of pH in the range 0-14, droplet temperature in the range 291-263 K and gas-liquid interaction time in the range 2-15 ms. For deuterated acetic acid the isotope exchange probability with water molecules at the interface is near unity. On the other hand, isotope exchange probability for ethanol with surface water molecules at pH 7 is much smaller, ranging from 0.033 at 263 K to 0.051 at 291 K. Ethanol isotope exchange is both acid and base catalyzed. The exchange probability therefore increases both toward low and high pH and levels off to a plateau at pH 2 and 12, respectively. The maximum value of the isotope exchange probability at the plateau is significantly less than I. It ranges between 0.14 and 0.18 with no clear trend in temperature. Results are explained in terms of a kinetic model in which it is assumed that the surface-adsorbed ethanol molecules are distributed between two distinct forms: a weakly adsorbed state and a partially solvated state. Only the partially solvated molecules can interact with the near-surface ions in the interior of the liquid. A finite rate of entering the partially solvated state is responsible for the observed plateaus in isotope exchange at high and low pH. Parameters describing the gas uptake and isotope exchange processes are examined using two models to describe the surface species: surface nucleation and Gibbs: surface excess.