Superparamagnetic nanomaterials are showing great prospects in medical treatment with targeted medicine. A new conductive superparamagnetic nanocomposite, gamma-Fe2O3/polyaniline-curcumin (gamma-Fe2O3/PANI-curcumin), has been synthesized using the interaction between amino group in polyaniline and ketone group in curcumin. The gamma-Fe2O3/PANI-curcumin composite has the superparamagnetism (30 emu.g(-1)) and electrochemical activity based on the results of magnetization curve and cyclic voltammetry (CV). Transmission electron microscope (TEM) shows that the particle size of gamma-Fe2O3/PANI-curcumin is about 50 nm. Fourier transform infrared spectra (FTIR) and X-ray diffraction (XRD) have been used to characterize the gamma-Fe2O3/PANI-curcumin composite and to confirm that curcumin is immobilized into gamma-Fe2O3/PANI chains. The study provides an academic foundation for developing some new material for immobilizing drugs of anticancer.