The objective of this study is to predict fluid flow and thermal characteristics associated with forced convection cooling of an array of heat sources mounted in a three-dimensional duct by impinging jets in the presence of cross flow. The equations governing fluid flow and heat transfer are solved using Streamline Upwind / Petrov-Galerkin based finite element method. The role of three dimensional flow structures, horseshoe vortex and counter rotating vortex pair in overall heat transfer distribution is examined. A parametric study is performed to analyze the performance of jets in cross flow for various Reynolds numbers (Re = 100, 250, 500) and velocity ratios (VR = 1.0, 5.0, 10.0). It is observed that with the increase in velocity ratio, the enhancement of heat transfer from heat sources occurs due to increase in the dominance of jet flow accompanied by an unfavorable reduction in heat transfer owing to the increase in size of horseshoe vortex. From numerical studies, it can be concluded that VR = 5.0 exhibits higher overall surface averaged Nusselt number (51.7% over VR = 1.0 and 44.1% over VR = 10.0 for Re = 500) compared to other velocity ratios considered in this study.