Nowadays, Fenton (Fe2+/H2O2) process is increasingly applied to wastewater treatment, however, the treatment efficiency would be inhibited largely when treated salty wastewater. To overcome this limitation, pre-magnetization (pre-magn-Fe-0)/H2O2 process was investigated to treat salty wastewater, which could enhance the degradation rate of organic pollutants (1.2-171.2 folds enhancement) and reduce reagents dosage (save 75% H2O2) in salty system compared with Fe-0/H2O2 process, using Orange G as the target pollutant and Na2SO4 as the model salty system. The characterizations by SEM, XRD and XPS and the intensity of DMPO-OH adduct signals in different processes confirmed this enhancement attributed to the increase of corrosion of Fe-0 inducing fast catalysis of H2O2 and generation of hydroxyl radicals. Pre-magn-Fe-0/H2O2 process could also have 5.9, 26.4 and 93.7 folds enhancement in NaCl, NaNO3 and Na2HPO4 salty system, respectively. Meanwhile, pre-magn-Fe-0/H2O2 process could keep close performance in Na2SO4 and NaCl salty systems and have better performance in NaNO3 and Na2HPO4 salty systems than Fenton process. Pre-magn-Fe-0/H2O2 process also had remarkable improvement (1.1-5.3 folds) on the removal of many refractory contaminants in salty system. Furthermore, it could also keep good performance in real reverse osmosis concentrated wastewater and petrochemical wastewater. Therefore, pre-magn-Fe-0/H2O2 process is a more cost-effective process to treat salty wastewater, which could have not only improved performance than conventional system and Fe-0/H2O2 process, but also good performance as Fenton process.