Heat exchanger (HEX) reactor is recognized as one of the most promising configurations for production of DME and hydrogen, simultaneously. In the current study, dehydration of methanol to DME is carried out in exo-thermic side, which is a fixed bed reactor assisted by regenerative zeolite 4A particles and coupled with benzene synthesis in endothermic side. The mathematical modeling results prove that selective water adsorption from direct DME synthesis leads to an intensification of DME production compared to non-adsorbent configuration as well as conventional one. Furthermore, the simulation results represent 336.52 ton/day enhancement in the hydrogen production rate in comparison with non-adsorbent configuration using the same catalyst loading and duty. Finally, the effects of main operating variables are considered on DME molar flow rate and cyclohexane conversion. The results suggest that the coupling of these reactions in the presence of zeolite 4A adsorbent could be feasible and beneficial. Experimental proof of concept is needed to establish the validity and safe operation of the novel reactor.