In this research, the Polysulfone (PS) membrane was blended with ZrO2-SnO2 nanocomposite as a promising tool for pharmaceutical wastewater to evaluate the impression of the synthesized ZrO2-SnO2 nanocomposite membrane on the efficiency and antibiofouling behaviors. The hydrophilicity, pharmaceutical wastewater permeability, photocatalytic activity and anti-fouling behavior of nanocomposite membranes were studied in details. The outcomes demonstrate that the nanocomposite membranes indicated considerable photocatalytic degradation of pharmaceutical wastewater under UV light irradiation during filtration separation, and nanocomposite membrane fouling could be remarkably diminished after UV irradiation, leading to high pharmaceutical wastewater treatment for long-term performance. The flux of the ZrO2-SnO2 nanocomposite membranes after being irradiated by UV light was increased significantly in comparison with an origin PS membrane. The results of PS0.5 membrane show the best flux of 73.78 l/m(2) h increase 50.7% compared to the neat membrane. Likewise, the degradation efficiency, COD removal and flux recovery ratio of this modified membrane was also improved to 90, 57.1 and 68.5%, respectively. The hydrophilicity of PS0.5 membrane under UV irradiation was realized with a decline from 62.9A degrees to 45.97A degrees. Our research indicates that ZrO2-SnO2 nanocomposite membranes with photocatalytic attributes under UV light are an impressive method to resolve the pharmaceutical wastewater fouling problem. [GRAPHICS]