Stability and in Vivo UV-Protecting Efficacy of Emulsions Stabilized with Cinnamoyl Surfactants

Seok Ho Park; Kyeongnan Kwon; Jin-Chul Kim

Korean Chemical Engineering Research, Vol.56, No.2, 143-150, April, 2018

DOI10.9713/kcer.2018.56.2.143 Export Citation

Stability and in Vivo UV-Protecting Efficacy of Emulsions Stabilized with Cinnamoyl Surfactants

Seok Ho Park, Kyeongnan Kwon, and Jin-Chul Kim^†

Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, 1, Gangwondaehak-gil, Chuncheon-si, Gangwon-do, 24341, Korea

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Oil-in-water emulsion was prepared using cinnamoyl surfactants as emulsifiers. Cinnamoyl surfactants used in the present study were polyoxyethylene (20) sorbitan monolaurate-cinnamic acid conjugate (TW20CA), polyoxyethylene (20) cetyl ether-cinnamic acid conjugate (CE20CA), and polyoxyethylene(20) oleyl ether cinnamic acid conjugate (OE20CA). The emulsion stabilized with TW20CA was the most stable, possibly because the polyoxyethylene segment of TW20CA would sterically stabilize the oil droplets effectively. In vivo UV protecting efficacy of surfactant and emulsion was investigated by determining the minimum amount of UV light (MAUL) to induce a black point on the back of hairless mice (HRM2). The mean MAUL of PARSOL, OE20CA, and emulsion stabilized with TW20CA was 1046.5 mJ/cm2, 1163 mJ/cm2, and 1308.5 mJ/cm2, respectively. The high UV protecting efficacy of the emulsion could be ascribed to not only the UV-absorbing property of cinnamoyl group but also the UV-scattering property of the oil droplets.

Keywords:Cinnamoyl Surfactant;Emulsifier;Droplet Stability;Emulsion;In Vivo UV Protecting Efficacy

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[2] Armstrong BK, Kricker A, J. Photochem. Photobiol. B-Biol., 63(1), 8 (2001)

[3] Tadokoro T, Yamaguchi Y, Batzer J, Coelho SG, Zmudzka BZ, Miller SA, Wolber R, Beer JZ, Hearing VJ, J. Invest. Dermatol., 124(6), 1326 (2005)

[4] Gilchrest BA, J. Am. Acad. Dermatol., 21(3), 610 (1989)

[5] Haase M, Weller H, Henglein A, J. Phys. Chem., 92(2), 482 (1988)

[6] Serpone N, Dondi D, Albini A, Inorg. Chim. Acta., 360, 794 (2007)

[7] Plass GN, Appl. Optics, 3(7), 867 (1964)

[8] Alfaro S, Lafon S, Rajot J, Formenti P, Gaudichet A, Maille M, J. Geophys. Res. Atmos., 109(D8), D08208 (2004)

[9] Manaia EB, Kaminski RCK, Correa MA, Chiavacci LA, Braz. J. Pharm. Sci., 49(2), 201 (2013)

[10] Sherly ED, Vijaya JJ, Kennedy LJ, Meenakshisundaram A, Lavanya M, Korean J. Chem. Eng., 33(4), 1431 (2016)

[11] Villalobos-Hernandez JR, Muller-Goymann CC, Eur. J. Pharm. Biopharm., 65(1), 122 (2007)

[12] Nohynek GJ, Dufour EK, Roberts MS, Skin Pharmacol. Physiol., 21(3), 136 (2008)

[13] Zenker A, Schmutz H, Fent K, J. Chromatogr. A, 1202(1), 64 (2008)

[14] Morabito K, Shapley N, Steeley K, Tripathi A, Int. J. Cosmet. Sci., 33(5), 385 (2011)

[15] Kim JC, J. Dispersion Sci. Technol., 37(1), 104 (2016)

[16] Tajima K, Koshinuma M, Nakamura A, Colloid Polym. Sci., 270(8), 759 (1992)

[17] Wang M, Kim JC, Colloids Surf. A: Physicochem. Eng. Asp., 453(1), 62 (2014)

[18] Remington JP, Remington: The Science and Practice of Pharmacy, 21st ed., Lippincott Williams & Wilkins, Philadelphia (2006).

[19] Griffin WC, J. Soc. Cosme. Chem, 1(5), 311 (1949)

[20] Lim JC, Mo DH, Lee JS, Park JS, Han DS, Korean Chem. Eng. Res., 50(3), 455 (2012)

[21] Shaath NA, Photochem. Photobiol. Sci., 9(4), 464 (2010)