Curcumin-Incorporated Polymeric Scaffolds and Their Potential for the Detection of Radical Molecules

Ok Park; Chae Hwa Kim; Yoon Jin Kim; Hee Sun Jung; Tae Hee Kim; Hyejung Mok

Macromolecular Research, Vol.26, No.2, 145-150, February, 2018

DOI10.1007/s13233-018-6025-0 Export Citation

Curcumin-Incorporated Polymeric Scaffolds and Their Potential for the Detection of Radical Molecules

Ok Park, Chae Hwa Kim¹, Yoon Jin Kim¹, Hee Sun Jung, Tae Hee Kim^{1, †}, and Hyejung Mok^†

Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea
¹Technical Textile R&D Group, Korea Institute of Industrial Technology (KITECH), Ansan, Gyeonggi 15588, Korea

E-mail:,

Reactive oxygen species (ROS)-responsive imaging systems could serve as probes for fluorescence detection at wound sites. In this study, curcumin-incorporated polymeric scaffolds were prepared, and their potential for the rapid detection of radical molecules as a wound stage marker was examined. Two types of nonwoven scaffolds, based on poly(lactic-co-glycolic) acid (PLGA)/poly(lactic acid) (PLA) and chitosan, with similar morphology and porosity were fabricated and analyzed by scanning electron microscopy (SEM). ROS-responsive curcumin was successfully incorporated into PLGA/PLA scaffolds via noncovalent hydrophobic interaction. Curcumin-incorporated PLGA/PLA scaffolds showed strong fluorescence intensities in PBS solution for 3 days. These fluorescence signals were significantly decreased by the radical molecule, 2,2-diphenyl-1-picrylhydrazyl (DPPH). This radical-derived oxidation of curcumin in scaffolds could be applied to ROS detection in vivo and ROS-related disease monitoring of conditions such as wounds and inflammation.

Keywords:porous scaffold;curcumin;radical-derived oxidation;PLGA/PLA;chitosan

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Kang YY, Jung H, Yu G, Chong Y, Mok H, Int. J. Pharm., 515, 669 (2016)
Tepe B, Sokmen M, Akpulat HA, Sokmen A, Food Chem., 92, 89 (2005)
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[1] Jayachandran M, Rodriguez S, Solis E, Lei J, Godavarty A, Adv. Wound Care (New Rochelle), 5, 349 (2016)

[2] Zhou J, Tun TN, Hong SH, Mercer-Chalmers JD, Laabei M, Young AER, Jenkins ATA, Biosens. Bioelectron., 30, 67 (2011)

[3] Pan CP, Shi Y, Amin K, Greenberg CS, Haroon Z, Faris GW, Biomed. Opt. Express, 1, 285 (2010)

[4] Hilderbrand SA, Weissleder R, Curr. Opin. Chem. Biol., 14, 71 (2010)

[5] Fang C, Wang K, Zeng C, Chi C, Shang W, Ye J, Mao Y, Fan Y, Yang J, Xiang N, Zeng N, Zhu W, Tian J, Sci. Rep., 6, 21013 (2016)

[6] Kim DH, Wang S, Keum H, Ghaffari R, Kim YS, Tao H, Panilaitis B, Li M, Kang Z, Omenetto F, Huang Y, Rogers JA, Small, 8, 3263 (2012)

[7] Zhang RL, Zhao J, Han GM, Liu ZJ, Liu C, Zhang C, Liu BH, Jiang CL, Liu RY, Zhao TT, Han MY, Zhang ZP, J. Am. Chem. Soc., 138(11), 3769 (2016)

[8] Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA, J. Med. Chem., 60, 1620 (2017)

[9] Griesser M, Pistis V, Suzuki T, Tejera N, Pratt DA, Schneider C, J. Biol. Chem., 286, 1114 (2011)

[10] Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY, Lin JK, J. Pharm. Biomed. Anal., 15, 1867 (1997)

[11] Gordon ON, Luis PB, Ashley RE, Osheroff N, Schneider C, Chem. Res. Toxicol., 28, 989 (2015)

[12] Kang YY, Jung H, Yu G, Chong Y, Mok H, Int. J. Pharm., 515, 669 (2016)

[13] Tepe B, Sokmen M, Akpulat HA, Sokmen A, Food Chem., 92, 89 (2005)

[14] Gordon ON, Schneider C, Trends Mol. Med, 18, 361 (2012)

[15] Schneider C, Gordon ON, Edwards RL, Luis PB, J. Agric. Food Chem., 63, 7606 (2015)

[16] Ak T, Gulcin I, Chem. Biol. Interact, 174, 27 (2008)

[17] Schafer M, Werner S, Pharmacol. Res., 58, 165 (2008)

[18] Spooner R, Yilmaz O, Int. J. Mol. Sci., 12(1), 334 (2011)

[19] Roy S, Khanna S, Nallu K, Hunt TK, Sen CK, Mol. Ther., 13, 211 (2006)