Nano scale and bio-based metal-organic frameworks (MOFs) are an important class of porous materials potentially used in biomedical application. Several green and facile synthetic methods have been developed in this regard. In this study, we have compared green synthetic methods in generating MOF and nano MOF containing biocompatible metal ion, i.e. zinc(II) and benzen 1,3,5-tri carboxylic acid (H3BTC) as linker to form [Zn-3(BTC)(2)] using electro- and sonochemicals method. The electrosynthesis of [Zn-3(BTC)(2)] performed at ambient temperature under voltage of 15 V in the solvent mixture of ethanol: water (1:1), whereas the sonochemistry conducted in the solvent mixture ethanol: water (1:1) at ambient temperatures and 40 MHz with a time variation of 90, 60 and 30 min. The obtained materials were loaded with ibuprofen for three days. The materials, before and after being loaded with ibuprofen, were fully characterized using X-ray diffraction analysis, FTIR, scanning electron microscopy (SEM) and transmission electron microscopy (TEM), surface area analyzer (SAA) and thermogravimetry analysis (TG/DTA). The electrochemical method tend to produce larger avarage particle size (ca. 18.43 +/- 8.10 mu m) of [Zn-3(BTC)(2)] than sonochemical method (with avarage particle size ca. 87.63 +/- 22.86 and 112.23 +/- 28.87 nm, for 30 and 60 min, respectively). Slow-release of ibuprofen was conducted in a phosphate buffered saline system (PBS) at 37 degrees C and pH 7.4. The concentration of loaded and released ibuprofen were monitored using UV-Vis spectroscopy. After 24 h, it showed that ibuprofen encapsulated into [Zn-3(BTC)(2)] have average release ca. 25.6 wt%, while ibuprofen without [Zn-3(BTC)(2)] is released ca. 85.9 wt%, then continued with a constant rate. This study demonstated that [Zn-3(BTC)(2)] could be afforded as a matrix to assist the slow-release of ibuprofen. (C) 2017 Elsevier B.V. All rights reserved.