Cutaneous leishmaniasis is a tropical disease which main treatment indicated by World Health Organization (WHO) is parenteral pentavalent antimony application; however the widespread usage of this drug is limited due to its toxicity, low efficiency and cost, and also requires medical assistance for application. Topical treatment is proposed using wound dressings with controlled drug delivery against cutaneous leishmaniasis, since dressings can control the water and oxygen permeability necessary for wound healing. This way, commercial wound dressings based on biopolymers (Spongostan and Promogran), were loaded with copaiba oil using supercritical solvent impregnation (SSI/SSD) as an alternative topical antileishmanial treatment. SSI/SSD experimental runs were carried out at 45 degrees C and for scCO(2) densities of 701, 801 and 900 kg/m(3). Results show that process conditions affect the oil impregnation with improvement of from 1.4 up to 3.8 times. The biopolymers affinities with copaiba oil, the sorption of scCO(2) in the biopolymers and copaiba oil solubility in scCO(2) shown to be important factors for the studied systems. Spongostan had improved its thermal stability, probably promoted by the copaiba oil plasticizing effect during the process. The main compound found in copaiba oil, P-caryophyllene, which presents leishmanicidal and anti-inflammatory activities, was successfully loaded using scCO(2) in both wound dressings, and showed to be promising to further analysis on leishmaniasis wound. (C) 2017 Elsevier B.V. All rights reserved.