The adsorption thermodynamics, kinetics, and isotherm parameters of cefpirome sulfate in aqueous solution on macroporous resin (XAD-16) were studied. Using static equilibrium tests, the fitting of resin adsorption data were calculated by the isothermal adsorption model. The fitting results show that Freundlich equation can adequately fit the adsorption isotherm. Meanwhile, the derived adsorption constants and their temperature dependencies from Freundlich isotherm had been used to calculate the corresponding thermodynamic quantities, such as the free energy of adsorption, heat, and entropy of adsorption. The thermodynamic data indicated that XAD-16 resin adsorption of cefpirome sulfate in aqueous solution was a spontaneous exothermic process, which was characterized by physical adsorption. The influences of initial concentration, bed height, and residence time on the breakthrough curve were examined by dynamic tests and the optimal parameters were defined.