Combustion power plants currently face major performance challenges, which require robust control design methods. Extensive relative gain analysis was conducted in this paper to generate plantwide control structures for a full-scale once-through circulating fluidized bed boiler. No such study has been reported before for steam boilers. The partial relative gain was employed to generate decentralized control structures based on integral controllability with integrity. The approach provided feasible control structures and verified that basic turbine-following boiler control is preferable in terms of controllability. The steady-state results were extended with the dynamic relative gain array for higher frequencies, which revealed that boiler-following control becomes feasible for faster disturbances. The results highlight the complex interactions between steam pressure and output electrical power control, as well as the loop interactions caused by the feedwater flow in the once-through steam path.