Renewable energy research in support of the generously developing choice for diesel fuel automobiles has been concentrated because of environmental causes and hurly burly into petroleum combat. The test has been conducted in a light duty single cylinder variable compression ratio (VCR) naturally aspirated multifuel research engine. Three input parameters, compression ratio (CR), injection pressure (IP), and injection timing (IT), are taken as input amends. In this study parameters are taken as 16, 17, and 18 for CR and 210 bar, 230 bar, and 250 bar for IP and 21 degrees, 23 degrees, and 25 degrees before top dead center (bTDC) for IT. Experimental trials have been planned via statistical tool like design of experiments (DoE) to outline the resulting output, such as performance and emission. Better performance and lesser exhaust pollution are the desirable output factors by optimizing the injection system and compression ratio parameters by factorial design. The confirmatory tests validated that the models developed using response surface methodology (RSM) are adequate to describe the effects of CR, IP, and IT on the performance and emission characteristics using all test fuels. The error in prediction using RSM is within 5%.