Ethylene is a fuel considered for high-speed ram- and scramjet combustion applications, mainly because of the short ignition delay time resulting from its high reactivity. Further research and development on these combustion systems would benefit from simulations of large eddy (LES) type, which allow some chemical detail to accurately predict combustion characteristics and pollutant formation. In the present work, a chemical kinetic mechanism suitable for LES is presented, consisting of 66 irreversible reactions between 23 species. The mechanism is extensively validated for combustion characteristics related to ignition and flame propagation over a wide range of pressure, temperature, and equivalence ratios that previously published mechanism of this size have not covered. Agreement with a detailed reference mechanism is good for ignition delay, flame temperature, and laminar burning velocities. In addition, overall concentration profiles of major stable products are in overall good agreement with a reference mechanism. The skeletal mechanism shows an overall good performance in combination with a numerical stability and short computation time, making it highly suitable for combustion LES.