Oilfield reservoirs exhibit a wide array of complexities that have great impact on the efficiency of oil production. Major challenges include delineating overall reservoir architecture and the distributions of the contained fluids. Reservoir crude oils consist of dissolved gases, liquids, and dissolved solids (the asphaltenes); the corresponding compositional variations and phase transitions within reservoirs greatly impact production strategies and economic value. Standard workflows for understanding reservoir (rock) architecture are subsumed in the discipline "geodynamics", which incorporates the initial rock depositional setting and subsequent alterations through geologic time to yield the present-day reservoir. However, reservoir fluids are not generally treated in such a systematic manner. Petroleum system modeling provides the timing, type, and volume of hydrocarbon fluids that charge into reservoirs. However, there is little treatment regarding how these fluids change after filling the reservoir. A significant limitation had been the lack of thermodynamic treatment of asphaltenes in reservoir crude oils. Consequently, projecting reservoir fluid properties away from the wellbore has been problematic. "Reservoir fluid geodynamics" (RFG) is the newly formalized discipline that incorporates changes in the distributions of reservoir fluids and phase transitions over geologic time. A key enabling advance is the recently developed ability to treat asphaltene gradients in oilfield reservoirs using the Flory-Huggins-Zuo equation of state (FHZ EoS) with its reliance on the Yen-Mullins model of asphaltenes. In addition, in situ downhole fluid analysis in oil wells provides accurate vertical and lateral fluid gradients in reservoirs in a cost-effective manner. Thermodynamic equilibrium can now be recognized; equilibrated fluids imply connected reservoirs, meaning a single flow unit. Disequilibrium fluid gradients imply ongoing or recent fluid processes in geologic time. The analysis of 35 oilfields (with more than 100 oil reservoirs) has allowed the identification of various reservoir fluid geodynamic processes. Some processes, such as biodegradation, have long been studied; nevertheless, even in these cases, inclusion of the thermodynamic modeling yields accurate predictions of distributions of key fluid attributes. Many other RFG processes are elucidated herein and are shown to impact major reservoir concerns for production. The resulting fundamental understanding of the physics and chemistry of these RFG processes enables measurements made at the wellbore to be used as a basis for accurate prediction of fluid properties throughout the reservoir.