The different pressure thermally coupled reactive distillation (DPT-RD) process is an attractive heat-integrated design in chemical engineering development processes. In this study, a rigorous simulation of the DPT-RD process for amyl acetate synthesis in a neat operation mode is performed using the Aspen Plus simulator. The economic feasibility and controllability of the DPT-RD process were evaluated based on the research of steady-state optimization and dynamic control. The optimum DPT-RD process in terms of the total annual cost (TAC) is screened. The results show that 33.74% reduction in energy consumption and 7.96% savings in TAC can be achieved by the DPT-RD process compared to the conventional reactive distillation. The control strategy of the DPT-RD process was developed and the basic control structure with proportional control and the improved control structure with temperature/composition cascade control were presented. The dynamic results indicate that the improved control structure can effectively handle disturbances of 20% in feed flow rate and of 5% in feed composition. Overall results demonstrate that the DPT-RD process is a promising approach for amyl acetate synthesis.