A novel integrated process of coagulation and adsorption was proposed for the advanced treatment of biologically pretreated coking wastewater. Results of laboratory, pilot, and industrial-scale experiments indicated that this one-step novel process can remove biorefractory pollutants, achieving the maximum chemical oxygen demand (COD) and cyanide removals of around 85.3% and 99.4%, respectively. Its effluent could meet the corresponding discharge standards without any further treatment, i.e., COD < 30 mg/L, cyanide < 0.1 mg/L, and improved effluent safety (lower toxicity). The easy operation and high efficiency of this method reflect its engineering- application potential in the tertiary treatment of coking wastewater.