Many long non-coding RNA (lncRNA) has recently been reported to be dysregulated and involved in the progression of non-small-cell lung cancer. However, the biological role of LOC730101 in NSCLC carcinogenesis remains unclear. In the present study, we found that LOC730101 was up-regulated in TCGA and GEO database, so were in NSCLC tissues and cell lines. Overexpression of LOC730101 prompted the proliferation of NSCLC both in vitro and in vivo while Silencing observed opposite phenomenon. Furthermore, we found that LOC730101 enhances the activity of Wnt/beta-catenin signaling to promote the progression of cell cycle and ultimate promotes cell proliferation and growth. Therefore, our study may provide a better understanding of the pathogenesis of NSCLC and indicates that LOC730101 may be a potential therapeutic target in NSCLC. (C) 2017 Published by Elsevier Inc.