This paper investigates the decentralized adaptive fault-tolerant control problem for a class of uncertain large-scale interconnected systems with disturbances and actuator faults including stuck, outage and loss of effectiveness. It is assumed that the upper bounds of the disturbances and stuck faults are unknown. The considered disturbances and unknown interconnections contain matched and mismatched parts. A decentralized adaptive control scheme with backstepping method is developed. Then, according to the information from the adaptive mechanism, the effects of both the actuator faults and the matched parts of disturbances and interconnections can be eliminated completely. Furthermore, cyclic-small-gain technique is introduced to address the mismatched interconnections such that the resulting closed-loop system is asymptotically stable with disturbance attenuation level gamma. Compared with the existing results, disturbance rejection property can be guaranteed for each subsystem. Finally, a simulation example of a large-scale power system is provided to show the effectiveness of the proposed approach. (C) 2017 Elsevier Ltd. All rights reserved.