Determination of diffusion coefficient and partition coefficient of photoinitiator 2-hydroxy-2-methylpropiophenone in nanoporous polydimethylsiloxane network and aqueous poly(ethylene glycol) diacrylate solution

Kwangin Shin; Hyeonji Yu; Jungwook Kim

Journal of Industrial and Engineering Chemistry, Vol.56, 443-449, December, 2017

DOI10.1016/j.jiec.2017.08.002 Export Citation

Determination of diffusion coefficient and partition coefficient of photoinitiator 2-hydroxy-2-methylpropiophenone in nanoporous polydimethylsiloxane network and aqueous poly(ethylene glycol) diacrylate solution

Kwangin Shin, Hyeonji Yu, and Jungwook Kim^†

Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Republic of Korea

E-mail:

We determine diffusion and partition coefficients of 2-hydroxy-2-methylpropiophenone, a widely used photo-initiator, in nanoporous polydimethylsiloxane network and poly(ethylene glycol) diacrylate solution as model precursor solution. We spectroscopically measure average concentration of 2-hydroxy- 2-methylpropiophenone in each media, which is compared to the one estimated from one-dimensional diffusion models to obtain diffusion coefficient. Partition coefficient is obtained by measuring saturated concentration of 2-hydroxy-2-methylpropiophenone in each media. Our results enables predicting concentration of 2-hydroxy-2-methylpropiophenone as it diffuses from precursor solution to crosslinked PDMS, which typically occurs when hydrogel is formed inside microfluidic device via photo- polymerization to create nano-structured or micro-structured hydrogel including microfluidic valves.

Keywords:Nanoporous polydimethylsiloxane network;Photo-initiator;Diffusion coefficient;Partition coefficient;Nano-structured or micro-structured;hydrogel

[References]

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[1] Kwakye S, Baeumner A, Anal. Bioanal. Chem., 376, 1062 (2003)

[2] Lee KH, Su YD, Chen SJ, Tseng FG, Lee GB, Biosens. Bioelectron., 23, 466 (2007)

[3] Sia SK, Whitesides GM, Electrophoresis, 24(21), 3563 (2003)

[4] Gossett DR, Weaver WM, Mach AJ, Hur SC, Tse HTK, Lee W, Amini H, Carlo DD, Anal. Bioanal. Chem., 397, 3249 (2010)

[5] Studer V, Jameson R, Pellereau E, Pepin A, Chen Y, Microelectron. Eng., 73-4, 852 (2004)

[6] Sundararajan N, Pio MS, Lee LP, Berlin AA, J. Microelectromech. Syst., 13, 559 (2004)

[7] Dang TD, Cheney MA, Qian S, Joo SW, Min BK, J. Ind. Eng. Chem., 19(6), 1770 (2013)

[8] Dang TD, Kim YH, Kim HG, Kim GM, J. Ind. Eng. Chem., 18(4), 1308 (2012)

[9] Bontoux N, Dauphinot L, Vitalis T, Studer V, Chen Y, Rossier J, Potier MC, Lab Chip, 8, 443 (2008)

[10] Gross PG, Kartalov EP, Scherer A, Weiner LP, J. Neurol. Sci., 252, 135 (2007)

[11] Ryley J, Pereira-Smith OM, Yeast, 23, 1065 (2006)

[12] Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE, Science, 328(5986), 1662 (2010)

[13] Kim HJ, Huh D, Hamilton G, Ingber DE, Lab Chip, 12, 2165 (2012)

[14] Baldi A, Gu YD, Loftness PE, Siegel RA, Ziaie B, J. Microelectromech. Syst., 12, 613 (2003)

[15] Dong L, Jiang H, Soft Matter, 3, 1223 (2007)

[16] Brower K, White AK, Fordyce PM, J. Vis. Exp. (119) Article number:e55276 (2017).

[17] Duncombe TA, Herr AE, Lab Chip, 13, 2115 (2013)

[18] He M, Herr AE, Anal. Chem., 81, 8177 (2009)

[19] Moreno-Arotzena O, Borau C, Movilla N, Vicente-Manzanares M, Garcia-Aznar JM, Ann. Biomed. Eng., 43, 3025 (2015)

[20] Logun MT, Bisel NS, Tanasse EA, Zhao WJ, Gunasekera B, Mao LD, Karumbaiah L, J. Mater. Chem., 4, 6052 (2016)

[21] Vincent LG, Choi YS, Alonso-Latorre B, del Alamo JC, Engler AJ, Biotechnol. J., 8, 472 (2013)

[22] Isenberg BC, DiMilla PA, Walker M, Kim S, Wong JY, Biophys. J., 97, 1313 (2009)

[23] Jeong GS, Han S, Shin Y, Kwon GH, Kamm RD, Lee SH, Chung S, Anal. Chem., 83, 8454 (2011)

[24] Bodas D, Khan-Malek C, Sens. Actuators B-Chem., 123, 368 (2007)

[25] Coelho EC, Dos Santos DP, Ciuffi KJ, Ferrari JL, Ferreira BA, Schiavon MA, J. Polym. Res., 21(561), 1 (2014)

[26] Hillerstrom A, Andersson M, Pedersen JS, Altskar A, Langton M, van Stam J, Kronberg B, J. Appl. Polym. Sci., 114(3), 1828 (2009)

[27] Li X, Cai XB, Gao YF, Serpe MJ, J. Mater. Chem., 5, 2804 (2017)

[28] Pescosolido L, Schuurman W, Malda J, Matricardi P, Alhaique F, Coviello T, van Weeren PR, Dhert WJA, Hennink WE, Vermonden T, Biomacromolecules, 12(5), 1831 (2011)

[29] Turner JS, Cheng YL, Macromolecules, 33(10), 3714 (2000)

[30] Crank J, The Mathematics of Diffusion, 2nd ed., Oxford University Press, Oxford, 1975.

[31] Schneider MH, Tran Y, Tabeling P, Langmuir, 27(3), 1232 (2011)

[32] Dendukuri D, Panda P, Haghgooie R, Kim JM, Hatton TA, Doyle PS, Macromolecules, 41(22), 8547 (2008)

[33] Linder PW, Nassimbeni LR, Polson A, Rodgers AL, J. Chem. Educ., 53, 330 (1976)

[34] Choi NW, Kim J, Chapin SC, Duong T, Donohue E, Pandey P, Broom W, Hill WA, Doyle PS, Anal. Chem., 84, 9370 (2012)

[35] Muller G, Narbeshuber T, Mirth G, Lercher JA, J. Phys. Chem., 98(31), 7436 (1994)

[36] From the Material Safety Data Sheet of Darocur 1173, a commercial name of the photoinitiator 2-hydroxy-2-methylpropiophenone, BASF Corporation, v3, 2014.

[37] Serth R, Lestina T, Process Heat Transfer: Principles, Applications and Rules of Thumb, 2nd ed., Academic Press, Cambridge, 2014.

[38] Lamberti A, Marasso SL, Cocuzza M, RSC Adv., 4, 61415 (2014)

[39] Markov DA, Lillie EM, Garbett SP, McCawley LJ, Biomed. Microdevices, 16, 91 (2014)

[40] Stafie N, Stamatialis DF, Wessling M, Sep. Purif. Technol., 45(3), 220 (2005)

[41] Cipolloni M, Gentili PL, Ortica F, Becker RS, Favaro G, Arkivoc, 205 (2011).

[42] Castro GT, Blanco SE, Giordano OS, Molecules, 5, 424 (2000)

[43] Pinsuwan S, Li A, Yalkowsky SH, J. Chem. Eng. Data, 40(3), 623 (1995)

[44] Lee JH, Prud’homme RK, Aksay IA, J. Mater. Res., 16, 3536 (2001)

[45] Schneider MH, Willaime H, Tran Y, Rezgui F, Tabeling P, Anal. Chem., 82, 8848 (2010)

[46] Waters DJ, Frank CW, Polymer, 50(26), 6331 (2009)