Journal of Supercritical Fluids, Vol.128, 166-172, 2017
Measurement and correlation of flavanone, tangeritin, nobiletin, 6-hydroxyflavanone and 7-hydroxyflavone solubilities in supercritical CO2
Solubilities of five flavonoids (flavanone, tangeritin, nobiletin, 6-hydroxyflavanone and 7-hydroxyflavone) were measured in supercritical CO2 at (313.2-333.2) K and at pressures up to 22 MPa. Among the solubility values of the flavonoids at 313 K, that of flavanone was the highest (similar to 10(-3) mol/mol) next to that of tangeritin and nobiletin which had almost the same range of solubility values (10(-6)-10(-5)), followed by 6-hydroxyflavanone (similar to 10(-7)) and 7-hydroxyflavone (similar to 10(-8)). Data had a maximum average relative deviation (ARD) of 1.69% from the Mendez-Santiago-Teja (MST) consistency test. The solubility of each flavonoid was correlated with the Peng-Robinson, entropy-based solubility parameter and a generalized form of the MST equation to within 3% ARD.
Keywords:Solubility;Flavonoids;Supercritical fluid extraction;Model;Natural products;Solubility parameter