Drying of multicomponent thin liquid films is an important step in coating and printing processes. In many cases, the substrate on which the film rests may possess topography, either intended or unintended. We present a lubrication-theory-based model describing the fundamentals of drying on such substrates. The film consists of volatile solvent and additional nonvolatile components such as colloidal particles, surfactants, and nonvolatile solvents. A system of one-dimensional partial differential equations accounting for the film height, depth-averaged concentration of bulk nonvolatile components, and interfacial concentration of insoluble surfactant is derived. Evaporation is included using the well-known one-sided description, and the governing equations are solved with finite-difference methods to study various limiting cases. The results highlight the influence of evaporation rate, and thermal, surfactant, and solutal Marangoni flows on the film thickness and colloidal particle distribution. We find that, in a realistic region of parameter space, the addition of a nonvolatile solvent yields a film that conforms to the substrate topography. (C) 2016 Wiley Periodicals, Inc.