Transverse injection is an effective mixing enhancement technique for the combustor of scramjets. Vibration of the plate structure in combustor will easily be induced due to aerodynamic load and harsh aerothermodynamic load simultaneously. Effects of the plate vibration on the mixing and the combustion of the transverse hydrogen injection have been investigated numerically in this study. Finite rate chemistry model is used as combustion model. The supersonic jet experimental model of the Stanford University is modified slightly and used as the analysis model. Effects of the frequency and the amplitude of the plate vibration on combustion performance and flow field structure have been investigated in detail. The results show that the plate vibration increases the mixing efficiency, the combustion efficiency and the total pressure loss coefficient. Besides, it can change the flame structure and the shock wave structure, as well as increase the shock wave intensity at downstream of the injection. The vibration frequency has relatively little effect on the combustion efficiency and the total pressure loss coefficient. When the vibration frequency is large, it presents some high frequency pulsations for the total pressure loss coefficient. However, the vibration amplitude has large effect on combustion efficiency and the total pressure loss coefficient. When the vibration amplitude is small, the combustion efficiency presents regular periodic change with time. When the vibration amplitude is large, it diverges with time, and the flow tends to be unstable. The large vibration amplitude changes the stability of the original flow. Consequently, the combustion with large amplitude fluctuation can critically damage the combustion stability. (C) 2017 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.