This Article presents removal of ibuprofen from aqueous solution using commercially available silk sericin as an adsorbent in an integrated adsorbent-membrane process. The adsorption study was performed at different physiological conditions, such as adsorbent concentration (110g), ibuprofen concentration (1070 mg/L), temperatures (20, 30, and 40 degrees C), and pH (5, 6, 7, and 8). The occurrence of adsorption before membrane separation was confirmed by performing analysis of sericinibuprofen interaction and complex formation. Sericinibuprofen interaction and complex formation was investigated using FTIR, FESEM, fluorescence spectroscopy, XRD, and ITC. Sericin and ibuprofen interaction is spontaneous and endothermic in nature, while random coil transition of Sericin governed the adsorption system. ITC analysis exhibited a binding affinity (K-b) value of 2.51 x 10(4) +/- 1.4 and one binding site (n approximate to 1) per molecule at 27 degrees C, revealing moderate binding of ibuprofen to the sericin protein. Complete removal of ibuprofen (at 10 mg/L, pH 8) was achieved using 10 g of sericin (pH 4) and at a temperature of 40 degrees C in reverse osmosis membrane process. The results established in this work concludes that sericin may be used as an adsorbent for the removal of micropollutants, such as ibuprofen from drinking water.