In this study, the performances of a solar energy assisted hybrid desiccant air conditioning system integrated with humidification dehumidification (HDH) desalination system are numerically investigated. The aim of this study is to benefit from the temperature rise of the regeneration air outside of the desiccant conditioning system as well as the water vapor content in this regeneration air by feeding it to the humidification-dehumidification water desalination unit to produce distillate water. The distillate water productivity, human thermal comfort issues, and energy saving represent the main objective of the present numerical study. The simulated results developed for subsystems are validated with the published experimental results. The effects of regeneration air temperature and flow rate on supply cooled air temperature, distillate water productivity, the cooling coefficient of performance and overall daily coefficient of performance of the proposed system are investigated. The results show that (i) the distillate water productivity increases from 3.175 to 5.011 L/h and overall daily coefficient of performance decreases from 4.392 to 3.636 with increasing the regeneration air temperature from 75 to 95 (as) (ii) the increase in the regeneration air flow rate from 70 to 130 m(3)/h, increases the distillate water productivity from 2.988 to 4.78 L/h and decrease the overall daily coefficient of performance from 4.66 to 3.386. The study demonstrates that the proposed system represents the best options in hot and humid regions.