Various computational fluid dynamics methods have been developed to study the hydrodynamics of gas-solid flows, however, none of those methods is suitable for all the problems encountered due to the inherent multiscale characteristics of gas-solid flows. Both discrete particle model (DPM) and two-fluid model (TFM) have been widely used to study gas-solid flows, DPM is accurate but computationally expensive, whereas TFM is computationally efficient but its deficiency is the lack of reliable constitutive relationships in many situations. Here, we propose a hybrid multiscale method (HMM) or dynamic multiscale method to make full use of the advantages of both DPM and TFM, which is an extension of our previous publication from rapid granular flow (Chen et al., Powder Technol. 2016; 304: 177-185) to gas-solid two-phase flow. TFM is used in the regions where it is valid and DPM is used in the regions where continuum description fails, they are coupled via dynamical exchange of parameters in the overlap regions. Simulations of gas-solid channel flow and fluidized bed demonstrate the feasibility of the proposed HMM. The Knudsen number distributions are also reported and analyzed to explain the differences. (C) 2017 American Institute of Chemical Engineers