This paper provides process design and simulation methodology for the separation of ethyl acetate and ethanol by extractive distillation using ionic liquids (ILs) as solvents and obtains the design parameters of extractive distillation process with solvent recovery system on the basis of a suitable IL solvent. The feasibility of IL-extractive distillation was examined via process simulation for the separation of ethyl acetate and ethanol in Aspen Plus. Four ILs [EMIM][MeSO3], [EMIM][MeSO4], [BMIM][CF3SO3] and [EMIM] [BF4] were created in Aspen Plus database with several thermodynamic and physical property parameters to allow the process to be simulated via the UNIFAC-Lei thermodynamic method. The results show that the separation process containing the hybrid regeneration system of flash tank and stripper with [EMIM] [MeSO3] as a suitable solvent is the best option in extractive distillation for the separation of ethyl acetate and ethanol compared with other ILs from the analysis of relative volatilities. The separation process was optimized by sensitivity analysis and the optimal design parameters were verified by economic evaluation based on the total annual cost (TAC). (C) 2017 Elsevier B.V. All rights reserved.