A full-scale three-dimensional Eulerian-Eulerian numerical model was established considering absorbing reactions in which the two-film theory model was adopted to describe the absorption process of SO2 and NOx. The established model was firstly verified by the industrial operation data of a 2 x 220 m(2) sintering flue gas desulfurization tower. Then, using the model, numerical simulations of simultaneous desulfurization and denitration process were carried out based on three different methods including spraying-inside tower oxidation absorption of the composited NaClO2/NaClO/Ca(OH)(2) slurry, oxidation absorption of the composited NaClO2/NaClO/Ca(OH)(2) slurry and bubble absorption of Ca(OH)(2) slurry. Numerical results revealed that the first method, spraying-inside tower oxidation absorption of the composited NaClO2/NaClO/Ca(OH)(2) slurry had the best performance on denitration without influencing on the desulfurization efficiency. The result was then further verified by an industrial scale test on a 2 x 220 m(2) sintering flue gas desulfurization tower. (C) 2016 Elsevier B.V. All rights reserved.