Resveratrol (RES), is a type of polyphenolic compound discovered from grapes and has gained prominence as a possible contributor to many disease treatments, Herein, three afferent types of liposomes were prepared as model cell membranes, and then the influence of the incorporation of RES on their membrane properties was, evaluated by utilizing' meinbfane,binding fluorescent prObeS. The binding of RES lead to the membrane polarities decreasing slightly, regardless of the phase states of the membrane, while the membrane 1 J I fluiditieS decreased only. n the case of liquid-disordered phase. In 041-model membrane system, the incorporation of RES dramatically dehydrated the-membrane surface, which could prevent the permeation of WatertSoluble materials. Fluorescence quenching of Laurdan indicated less, accessibility of hydroxyl radial into the inner region of-the",-RES-incorporated membrane. The- comparison between the mass spectra of oxidized DOPC 'molecules treated with hydroxyl radical revealed 'that the RESEincorporation into DOPC membranes can contribute to prevent lipid oxidatiOn. It is concluded that the binding of RES to the lipid membrane can play a key role in affecting membrane properties and functions.