This paper presents an energy and exergy analysis of a domestic refrigeration system using R1234yf as a drop-in replacement for R134a. We base our analysis on a series of independent tests using two refrigerants, namely R1234yf and R134a. The test equipment consists of a fully instrumented domestic refrigeration system. A computational model is developed to work out the thermodynamic parameters such as coefficient of performance, exergy destruction ratio, exergy-based rational efficiency, component efficiency defect as well as the dimensionless exergy balance for both refrigerants. The parameters varied in the analysis were the evaporator and condenser temperatures as well as the amount of refrigerant used in the system. The results indicate that irreversibilities are mainly concentrated in the compressor, this is the case both for R1234yf and R134a. This exergy analysis proposed for evaluation of refrigerants in domestic refrigerators permitted to determine that R1234yf may not be a likely alternative to R134a. (C) 2017 Elsevier Ltd. All rights reserved.