Cone-copositive piecewise quadratic Lyapunov functions (PWQ-LFs) for the stability analysis of continuous-time piecewise affine (PWA) systems are proposed. The state space is assumed to be partitioned into a finite number of convex, possibly unbounded, polyhedra. Preliminary conditions on PWQfunctions for their sign in the polyhedra and continuity over the common boundaries are provided. The sign of each quadratic function is studied by means of cone-constrained matrix inequalities which are translated into linear matrix inequalities (LMIs) via cone-copositivity. The continuity is guaranteed by adding equality constraints over the polyhedra intersections. An asymptotic stability result for PWA systems is then obtained by finding a continuous PWQ-LF through the solution of a set of constrained LMIs. The effectiveness of the proposed approach is shown by analyzing an opinion dynamics model and two saturating control systems. (C) 2017 Elsevier Ltd. All rights reserved.