NETmix is a novel static mixing technology consisting on a network of unit cells, comprising chambers interconnected by channels. To assess the heat transfer capacity of NETmix, the NUB model was implemented to perform hydrodynamics and heat transfer simulations. Due to the periodic nature of the NETmix structure, two central chambers and six half-chambers were found to be sufficient to be representative of the whole network. The Nusselt numbers were determined based on the CFD simulations, and when compared with theoretical results for laminar flow between parallel plates, 3-5 times higher Nusselt number values were obtained with NETmix. This observed heat transfer rate enhancement, makes it suitable for fast reactions where heat transfer is crucial. Finally, results obtained from this study show that NETmix presents a heat transfer capacity one order of magnitude greater than microreactors, and 2-5 orders of magnitude greater than the most commonly used devices in industry. (c) 2017 American Institute of Chemical Engineers AIChE J, 63: 2496-2508, 2017