Novel Chemi-Dynamic Nanoparticles as a Light-Free Photodynamic Therapeutic System for Cancer Treatment

S. V. Berwin Singh; Jihye Kim; Hoyeon Park; Gilson Khang; Dongwon Lee

Macromolecular Research, Vol.25, No.7, 749-755, July, 2017

DOI10.1007/s13233-017-5078-9 Export Citation

Novel Chemi-Dynamic Nanoparticles as a Light-Free Photodynamic Therapeutic System for Cancer Treatment

S. V. Berwin Singh, Jihye Kim, Hoyeon Park, Gilson Khang , and Dongwon Lee^†

Department of BIN Convergence Technology, Chonbuk National University, Jeonju, Jeonbuk 54896, Korea

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Photodynamic therapy (PDT) is a treatment modality, in which photosensitizers are activated by light of appropriate wavelength to convert molecular oxygen from triplet state (3O2) to singlet (1O2) that kills nearby cancer cells. However, the clinical application of PDT is limited to treat tumors on or just below the skin or the lining of internal organs because the light needed cannot pass through more than 1 cm of tissues. Here, we report chemi-dynamic nanoparticles (CDNP) as a light-free photodynamic therapeutic system based on peroxalate chemiluminescence. Photosensitizers are excited by the energy generated from hydrogen peroxide- mediated degradation of peroxalate to generate singlet oxygen to kill cancer cells. CDNP kill cancer cells without external light and hold potential as new anticancer drugs.

Keywords:photodynamic therapy;peroxalate chemiluminescence;cancer;micelles;chemi-dynamic therapy

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[2] Mariotto AB, Yabroff KR, Shao Y, Feuer EJ, Brown ML, J. National Cancer Institute, 103, 117 (2011)

[3] Diamond I, McDonagh A, Wilson C, Granelli S, Nielsen S, Jaenicke R, Lancet, 300, 1175.

[4] Kelley EE, Domann FE, Buettner GR, Oberley LW, Burns CP, J. Photochem. Photobiol. B-Biol., 40, 273 (1997)

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[6] Alexiades-Armenakas M, Clinics Dermatol., 24, 16 (2006)

[7] Aquaron R, Forzano O, Murati JL, Fayet G, Aquaron C, Ridings B, Cell. Mol. Biol., 48, 925 (2002)

[8] Vrouenraets MB, Visser GWM, Snow GB, van Dongen G, Anticancer Res., 23, 505 (2003)

[9] Rose AL, Waite TD, Anal. Chem., 73, 5909 (2001)

[10] da Silva LP, da Silva J, ChemphysChem, 13, 2257 (2012)

[11] Magalhaes CM, da Silva J, da Silva LP, ChemphysChem, 17, 2286 (2016)

[12] Laptev R, Nisnevitch M, Siboni G, Malik Z, Firer MA, British J. Cancer, 95, 189 (2006)

[13] Theodossiou T, Hothersall JS, Woods EA, Okkenhaug K, Jacobson J, MacRobert AJ, Cancer Res., 63, 1818 (2003)

[14] Lee D, Khaja S, Velasquez-Castano JC, Dasari M, Sun C, Petros J, Taylor WR, Murthy N, Nat. Mater., 6(10), 765 (2007)

[15] Nogueira V, Hay N, Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 19, 4309 (2013).

[16] Lin LT, Tai CJ, Chang SP, Chen JL, Wu SJ, Lin CC, Anticancer Agents Med. Chem., 13, 1565 (2013)

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[18] Seo YH, Singh A, Cho HJ, Kim Y, Heo J, Lim CK, Park SY, Jang WD, Kim S, Biomaterials, 84, 111 (2016)

[19] Kim B, Lee E, Kim Y, Park S, Khang G, Lee D, Adv. Funct. Mater., 23, 5091 (2013)

[20] Park S, Yoon J, Bae S, Park M, Kang C, Ke Q, Lee D, Kang PM, Biomaterials, 35, 5944 (2014)

[21] Yoo D, Guk K, Kim H, Khang G, Wu D, Lee D, Int. J. Pharm., 450, 87 (2013)

[22] Lee D, Bae S, Ke Q, Lee J, Song B, Karumanchi SA, Khang G, Choi HS, Kang PM, J. Control. Release, 172, 1102 (2013)

[23] Liu ZH, Liu DH, Wang LL, Zhang JA, Zhang N, Int. J. Mol. Sci., 12(3), 1684 (2011)

[24] Yang YT, Chen CT, Yang JC, Tsai T, AAPS J., 12, 138 (2010)

[25] Gomes A, Fernandes E, Lima JLFC, J. Biochem. Biophys. Methods, 65, 45 (2005)

[26] Rapozzi V, Zorzet S, Zacchigna M, Pietra MD, Cogoi S, Xodo LE, Mol. Cancer, 13, 75 (2014)

[27] Jung SN, Shin DS, Kim HN, Jeon YJ, Yun J, Lee YJ, Kang JS, Han DC, Kwon BM, Biochem. Pharmacol., 97, 38 (2015)

[28] Noh J, Kwon B, Han E, Park M, Yang W, Cho W, Yoo W, Khang G, Lee D, Nat. Commun., 6, 6907 (2015)

[29] Taatjes DJ, Sobel BE, Budd RC, Histochem. Cell Biol., 129, 33 (2008)

[30] Bortner CD, Cidlowski JA, J. Biol. Chem., 278, 39176 (2003)

[31] Bown SG, Rogowska AZ, Whitelaw DE, Lees WR, Lovat LB, Ripley P, Jones L, Wyld P, Gillams A, Hatfield AW, Gut, 50, 549 (2002)