Mitigating membrane fouling by using turbulence promoters (TP) is an important issue in the microfiltration field. Considering the particles accumulation on the walls of permeable membrane tubes (one kind of fouling mechanism) with TP, we proposed a three-dimensional numerical model for random decision that decides particle movement on the membrane boundary. We investigated and predicted the permeate flux, fouling layer thickness and optimal TP arrangement modes with different operational parameters with this model. The dynamics process of cake deposition was precisely quantified and visualized. And then the simulated results ignored of pore blockage for the permeation flux were deviated less than 10% compared with the experimental data in literatures. After TP condition being optimized, the mass transfer resistance sharply reduced. Average thickness of the cake layer decreased from 0.318 mm to 0.026 mm, and the permeate flux increased more than 60%. (C) 2017 Elsevier B.V. All rights reserved.