In this work, the disinfection of 100 mL of 10(6) CFU center dot mL-1 Pseudomonas aeruginosa suspensions at pH 5.8 by electrochemical oxidation at 33.3 mA cm(-2) is reported. The undivided electrolytic cell was equipped with either a boron-doped diamond (BDD) or an IrO2-based or RuO2-based dimensionally stable anode and a stainless steel cathode. Physisorbed hydroxyl radicals M((OH)-O-center dot) formed from anodic water oxidation and active chlorine generated from anodic Cl-oxidation were the main oxidizing species in pure Na2SO4 medium and in the presence of NaCl, respectively. A faster inactivation was always found using the dimensionally stable anodes. In 7 mM Na2SO4, this behavior was associated to the much larger adsorption of the bacteria onto the anode, which accelerated the M((center dot)0H)-mediated oxidation and inactivation of the cells. The inactivation rate was strongly enhanced in 7 mM Na2SO4 + 1 mM NaCl due to the larger oxidation power of active chlorine compared to that of KOH). The effect of NaCl concentration and current density on the disinfection process was examined with BDD and the best performance was obtained in 7 mM Na2SO4 + 7 mM NaCl at 8.3 mA cm(2), with total inactivation in 2 min and energy consumption of 0.059 kW h m(-3). The addition of paracetamol in 7 mM Na2SO4 medium inhibited the disinfection at short electrolysis time regardless of the anode, owing to the preferential action of M(OH) on this pollutant. For BDD, the inactivation rate rose over time at higher drug content due to the generation of greater amounts of toxic by-products. For the IrO2-based anode, the progressive formation of toxic and less adsorbable by-products enhanced the process over time, giving rise again to a quicker total disinfection compared to that with BDD. (C) 2017 Elsevier B.V. All rights reserved.