Transition metal compounds with quasi-two-dimensional structure demonstrate a series of unprecedent quantum phases, such as topological insulator, topological phase transition under thermal/ pressure stimuli, which is attributed to delicate interplay among interlayer coupling, spin-orbit coupling and stoichiometry. Here, Cu2TlSe2 and Cu2TITe2 crystals were successfully synthesized by Bridgeman method. Highly crystalline quality of these samples is verified by X-ray diffraction and microstructural characterization. Temperature-dependent-Hall-resistivity shows that Cu2TlSe2 is hole-like and Hall resistivity is in-sensitive to temperature; while Hall resistivity of Cu2TlTe2 is positive at room temperature and change to negative at 30 K. Combined experimental results and electronic band structures calculated by first-principles method, it is revealed that Cu2TlSe2 is a metal, but Cu2TITe2 is a semi-metal. This work demonstrates the rich physical phases of layered transition metal compounds under the interplay among interlayer coupling, spin-orbit coupling and stoichiometry. (C) 2017 Published by Elsevier Ltd.