The two-dimensional framework of nickel seamed hexameric metal organic nanocapsules has been synthesized by connecting the tailed hydroxyl groups of Cpropan-3-ol pyrogallol[4]arene with adjacent hexameric capsules via nickel-hydroxyl coordination. In addition, functionalization of nanocapsules with multiple pyridine molecules at the capsule surface prevents them from assembling into hierarchical structures and leads to the formation of discrete nickel-seamed pyrogallol[4]arene nanocapsules. This work shows that surface functionalization of nanocapsules is an effective and innovative method of controlling the assembly of these nanometric building blocks.