In the present work, novel RGO/Ag-Au/Cu2O ternary nanocomposites electrochemical sensor for the detection of H2O2 has been successfully constructed. Due to the high conductivity of (reduced graphene oxide) RGO, the electrochemical activity of the binary Ag-Au/Cu2O nanocomposites can be significantly prompted when introduction of RGO. The cyclic voltammetry curves (CV) amperometry results indicated the optimum RGO/Ag-Au/Cu2O ternary nanocomposites showed good electrocatalytic activity for H2O2 reduction, with a linear response range from 0.05 to 50.75 mmol/L at -02 V and a sensitivity of 0.14 mu A mmol/L-1 cm(-2). In addition, the RGO/Ag-Au/Cu2O sensor exhibited good selectivity. The excellent electrocatalytic sensor performance might be ascribed to the synergistic effect of the Ag-Au bimetallic alloys and the RGO contributed to the high electrochemical activity. (C) 2017 Published by Elsevier B.V.