Purpose: Bleaching agents are claimed to impair the bonding to the tooth structure when resin composite restorations are immediately performed. This study aimed to evaluate the effect of a neutralizing solution (10% sodium bicarbonate) or an antioxidant agent (10% sodium ascorbate) on the immediate or delayed (15 days) shear bond strength (SBS) of composite restorations performed on enamel. Seventy flat buccal enamel surfaces obtained from bovine incisors were divided into seven groups (n = 10): control group, unbleached enamel, restored (3M ESPE/Adper Single Bond 2/Filtek Z350XT) (G1); bleached, immediately restored (G2); bleached, delayed restoration (G3); bleached, antioxidant (sodium ascorbate), immediately restored (G4); bleached, antioxidant, delayed restoration (G5); bleached, neutralizing (sodium bicarbonate), immediate restoration (G6); bleached, neutralizing, delayed restoration (G7). Specimens were submitted to SBS test and examined after failure using scanning electron microscopy (SEM). Results were statistically analyzed with ANOVA/Tukey's tests (5%). Bonding to enamel immediately restored after bleaching (G2) was significantly lower than G1 (unbleached enamel; p < 0.05). Applying the antioxidant or neutralizing agent significantly improved the bonding to enamel compared with G2 (bleached, immediate restored), irrespective of the restoration time (immediate or delayed) (p < 0.05). No significance was found between the two agents when applied after bleaching, and compared with the control group, regardless of evaluation time (p > 0.05). SEM images demonstrated adhesive failures in the bleached, immediately restored group (G2). G3-G7 exhibited majority of cohesive and mixed failure patterns. 10% sodium bicarbonate or 10% sodium ascorbate neutralizes the negative immediate and delayed effects of bleaching on bond strength of enamel bleached enamel.